°®ÓÎÏ·¹ÙÍøÈ«ÇòÒâ¼×ÔÞÖúÉÌ

°®ÓÎÏ·¹ÙÍøÈ«ÇòÒâ¼×ÔÞÖúÉÌÐÂÎÅÍø
ɽ´óÓÊÏä | Ͷ¸åϵͳ | ¸ß¼¶¼ìË÷ | ¾É°æ»Ø¹Ë

°®ÓÎÏ·¹ÙÍøÈ«ÇòÒâ¼×ÔÞÖúÉÌ: ÊÓµãÊ×Ò³ > ѧÊõ×ݺá > ÕýÎÄ

°®ÓÎÏ·¹ÙÍøÈ«ÇòÒâ¼×ÔÞÖúÉÌ:µ¤Âó¸ç±¾¹þ¸ù´óѧÁÖ½ðÖÓ×ö¿Í¡°É½º£ÖªÎ¢¡±ÂÛ̳

·¢²¼ÈÕÆÚ£º2024Äê07ÔÂ09ÈÕ 08:01 µã»÷´ÎÊý£º

£Û±¾Õ¾Ñ¶£Ý7ÔÂ5ÈÕ£¬µ¤Âó¸ç±¾¹þ¸ù´óѧÉúÎïϵÖúÀí½ÌÊÚÁÖ½ðÖÓ×ö¿Í¡°É½º£ÖªÎ¢¡±ÏµÁÐÂÛ̳£¬×÷ÁËÒÔ¡°Type III CRISPR-Cas£ºMolecular mechanism of and regulation by anti-CRISPR proteins£¨IIIÐÍCRISPR-Cas¼°Æ俹CRISPRµ°°×µÄ·Ö×Ó»úÖÆÑо¿£©¡±ÎªÌâµÄѧÊõ±¨¸æ¡£±¾´Î½²×ùÓÉ°®ÓÎÏ·¹ÙÍøÈ«ÇòÒâ¼×ÔÞÖúÉÌ΢ÉúÎï¼¼Êõ¹ú¼ÒÖصãʵÑéÊÒ½ÌÊÚÙÜȺÐÂÖ÷³Ö¡£

CRISPR-CasϵͳÊǹ㷺´æÔÚÓڹžúºÍϸ¾úÖеĻñµÃÐÔ¿¹²¡¶¾ÃâÒßϵͳ£¬¿ÉÒÔ»ñÈ¡²¡¶¾ºËËáƬ¶Î²¢ÒÔ¸ÃƬ¶Îת¼²úÉúµÄcrRNA×÷Ϊ̽Õë°ÐÏò²¡¶¾»ùÒò×飬½ø¶ø½«Æä½µ½âÒÔ·¢»ÓÃâÒß¹¦ÄÜ¡£ÓëÖ®Ïà¶ÔµÄÊÇ£¬²¡¶¾ÔÚÓëCRISPR-CasϵͳµÄ³¤ÆÚ¶Ô¿¹¹ý³ÌÖÐÒ²½ø»¯³öÁËÄܹ»ÒÖÖÆÆä»îÐԵĿ¹CRISPR£¨Anti-CRISPR, Acr£©µ°°×£¬Ê¹²¡¶¾Äܹ»ÔÚCRISPRÃâÒß¹ý³ÌÖдæ»îÏÂÀ´¡£Ñо¿CRISPR-CasϵͳÓ뿹CRISPRµ°°×µÄ·Ö×Ó»úÖƶÔÓÚÁ˽âÔ­ºËÉúÎïÓëÆ䲡¶¾Ö®¼äµÄ»¥×÷ÒÔ¼°¹²½ø»¯¹Øϵ¾ßÓÐÖØÒªÒâÒ壬Ҳ¿ÉÒÔΪ¿ª·¢ÐµÄÉúÎïѧ¼¼Êõ·¢¾òÐÂÐÍÔª¼þ¡£ÔÚ²»Í¬ÀàÐÍCRISPR-CasϵͳÖУ¬IIIÐÍCRISPR-Cas10ϵͳµÄЧӦ×ÓÓÉcrRNAºÍ¶à¸öµ°°×ÑÇ»ù×é³É£¬¾ßÓй¦ÄܶàÑù»¯µÄÌص㣬Äܹ»°ÐÏòÇиîÄ¿±êRNA£¬Ò²¾ßÓÐÄ¿±êRNA¼¤»îµÄDNase»îÐÔÒÔ¼°cOAÐźÅͨ·¡£ÁÖ½ðÖÓÖúÀí½ÌÊÚ³¤ÆÚÒÔÀ´¾Û½¹ÓÚIIIÐÍCRISPR-Cas10ϵͳÃâÒß¹¦ÄܺÍ×÷ÓûúÖƵÄÑо¿£¬ÔÚ±¾´Î±¨¸æÖÐÊ×ÏÈϵͳµØ½éÉÜÁËIIIÐÍϵͳµÄÑо¿ÀúÊ·¼°ÆäÒÑÖªµÄ¹¦ÄÜÌص㣬Ëæºó¶Ô×Ô¼ºÔÚ¸ÃÁìÓòÈ¡µÃµÄ½øÕ¹½øÐÐÁËÏêϸ»ã±¨¡£µÚÒ»²¿·Ö¹¤×÷Ö÷ÒªÒÔ±£¼ÓÀûÑÇÈé¸Ë¾úIII-AÐÍϵͳΪģʽÌåϵ¶ÔÆäDNase»îÐԽ鵼µÄÃâÒß¹¦ÄܽøÐÐÁËÑо¿£¬½ÒʾÁËIIIÐÍϵͳDNase»îÐÔͨ¹ýÇиî·ÇÌØÒìÐÔDNAƬ¶ÎµÄת¼ÅÝÒý·¢Ï¸¾ú»ùÒò×éËðÉ˽ø¶øµ¼ÖÂËÞÖ÷ϸ¾úËÀÍöµÄÃâÒß»úÖÆ£»µÚ¶þ²¿·Ö¹¤×÷Ö÷ÒªÒÔ±ùµºÁò»¯Ò¶¾úIII-BÐÍϵͳΪģʽÌåϵɸѡÁËÁ½ÖÖÐÂÐ͵Ŀ¹IIIÐÍCRSPRµ°°×AcrIIIB1ºÍAcrIIIB2²¢¼ø¶¨ÁËÆ书ÄÜ£¬Ö¤Ã÷ËüÃǾßÓÐRNA½áºÏ¹¦ÄÜÇÒÄܹ»×èֹĿ±êRNAÇиî²úÎï´ÓIII-BÐÍЧӦ×ÓµÄÊÍ·Å£¬ÆäÖÐAcrIIIB2ͨ¹ý×èÖ¹III-BÐÍЧӦ×ÓÓëÐÂÒ»ÂÖÄ¿±êRNAµÄ½áºÏ´Ó¶øÒÖÖÆÁËIII-BϵͳµÄÃâÒß»îÐÔ¡£ÉÏÊö¹¤×÷ʵÏÖÁËIIIÐÍCRISPRϵͳ¼°Æ俹CRISPRµ°°×Ïà¹ØÑо¿ÁìÓòµÄÀíÂÛÍ»ÆÆ£¬¶Ô¸üÉîÈëµØÈÏʶԭºËÉúÎï¼°Æ䲡¶¾µÄ¡°¾ü±¸¾ºÈü¡±¶ÔËüÃÇÖ®¼ä¹²½ø»¯¹ØϵµÄÓ°Ïì¾ßÓÐÖØÒªÒâÒå¡£

±¨¸æ½áÊøºó£¬²Î»áʦÉúÓëÁÖ½ðÖÓÖúÀí½ÌÊÚ¾ÍIIIÐÍCRISPR-Cas10ϵͳÔÚ°ÐÏò²¡¶¾ÔçÆÚºÍÍíÆÚ»ùÒòʱ¸ÉÉæЧ¹ûµÄ²îÒ죬IIIÐÍÓëÆäËûÀàÐÍCRISPR-CasϵͳµÄÅÔÇлîÐÔÒý·¢²»Í¬¸ÉÉæЧ¹ûµÄÔ­Òò£¬IIIÐÍϵͳÇиîÄ¿±êRNAºóʧ»îµÄÔ­Òò£¬CRISPR-CasÏà¹ØµÄÒÅ´«²Ù×÷ϵͳµÄ½¨Á¢·½·¨ÒÔ¼°CRISPR-CasϵͳÏà¹ØµÄÑо¿·½°¸µÄÓÅ»¯µÈÎÊÌâ½øÐÐÁËÉîÈë½»Á÷ºÍÌÖÂÛ¡£

ÁÖ½ðÖÓ£¬µ¤Âó¸ç±¾¹þ¸ù´óѧÉúÎïѧϵÖúÀí½ÌÊÚ¡£2014ÄêÓÚ»ªÖÐÅ©Òµ´óѧ»ñµÃ΢ÉúÎïѧ˶ʿѧ룬2019ÄêÓÚµ¤Âó¸ç±¾¹þ¸ù´óѧ»ñµÃÉúÎïѧ²©Ê¿Ñ§Î»¡£Ö÷ÒªÑо¿·½Ïò°üÀ¨¸ÉÀÒÈéËá¾úÒÅ´«²Ù×÷ϵͳµÄ¿ª·¢£¬±£¼ÓÀûÑÇÈé¸Ë¾úIII-AÐÍCRISPR-Casϵͳ×÷ÓûúÖƵÄÑо¿£¬±ùµºÁò»¯Ò¶¾úI-DÐͺÍIII-BÐÍCRISPR-Casϵͳ×÷ÓûúÖƵÄÑо¿£¬ÒÔ¼°IIIÐÍCRISPR-CasϵͳµÄ¿¹CRISPRµ°°×µÄ·¢¾òµÈ¡£ÔÚMolecular Cell£¬Cell Host Microbe£¬Nucleic Acids Research£¬Nature Communications£¬Cell discoveryµÈѧÊõÆÚ¿¯·¢±íÑо¿ÂÛÎÄ14ƪ¡£


¡¾¹©¸åµ¥Î»£ºÎ¢ÉúÎïÑо¿Ôº    ×÷ÕߣºÓÚÕñÏö    ÉãÓ°£ºÖ£ÈçÒâ         ±à¼­£ºÐÂÎÅÍø¹¤×÷ÊÒ    ÔðÈα༭£º½¯Ïþº­ ÕÔºê¶÷ ¡¡¡¿

 ÄäÃû·¢²¼ ÑéÖ¤Âë ¿´²»Çå³þ,»»ÕÅͼƬ
¹²0ÌõÆÀÂÛ    ¹²1Ò³   µ±Ç°µÚ1Ò³ Í϶¯¹â±ê¿É·­Ò³²é¿´¸ü¶àÆÀÂÛ

ÃâÔðÉùÃ÷

ÄúÊDZ¾Õ¾µÄµÚ£º λ·Ã¿Í

ÐÂÎÅÖÐÐĵ绰£º0531-88362831 0531-88369009 ÁªÏµÐÅÏ䣺xwzx@sdu.edu.cn

½¨ÒéʹÓÃIE8.0ÒÔÉÏä¯ÀÀÆ÷ºÍ1366*768·Ö±æÂÊä¯ÀÀ±¾Õ¾ÒÔÈ¡µÃ×î¼Ñä¯ÀÀЧ¹û

»¶Ó­¹Øעɽ´óÊÓµã΢ÐÅ

°®ÓÎÏ·¹ÙÍøÈ«ÇòÒâ¼×ÔÞÖúÉÌ(Öйú)ÓÐÏÞ¹«Ë¾